' 
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: About 1/4 cup (31 g)
Amount Per Serving
%DV
Calories
180
Total Fat
13 g
17%
Saturated Fat
3 g
15%
Trans Fat
0 g
Cholesterol
0 mg
0%
Sodium
0 mg
0%
Total Carbohydrate
4 g
1%
Dietary Fiber
2 g
7%
Total Sugars
0 g
Includes 0g Added Sugars
0%
Protein
11g
Vit. D
0 mcg
0%
Calcium
8 mg
0%
Iron
4 mg
20%
Potassium
243 mg
6%
Top Medical Research Studies
9
Targeted HS delivery alleviates RA
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.
High relevance to RA treatment
We explored a new strategy to treat rheumatoid arthritis (RA) by using nanoparticles to deliver hydrogen sulfide (HS) directly to affected joints. Our research focused on how effectively these nanoparticles, called NaHS@Cy5@MS@SP, could target specific cells involved in inflammation and tissue damage in RA. By slowly releasing HS in the synovium, we aimed to combat the negative effects of inflammation caused by fibroblast-like synoviocytes (FLSs).
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Read More
9
Hydrogel enhances uveitis treatment
Peptide-based hydrogel co-assembled with antibody-drug for enhanced retinal cell uptake and attenuated experimental autoimmune uveitis.
Directly addresses autoimmune treatment
We investigated a new approach to tackle chronic autoimmune eye diseases like uveitis. Our attention focused on a unique drug delivery system that combines a peptide-based hydrogel with secukinumab (SEK), an antibody specifically designed to neutralize IL-17A. This combination targets retinal pigmented epithelium (RPE) cells, helping to enhance the treatment's effectiveness.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Read More
8
A. muciniphila benefits autoimmune conditions
Akkermansia muciniphila Modulates Central Nervous System Autoimmune Response and Cognitive Impairment by Inhibiting Hippocampal NLRP3-Mediated Neuroinflammation.
Direct relevance to autoimmune treatment
We investigated the effects of a probiotic called Akkermansia muciniphila (A. muciniphila) on autoimmune disorders, specifically its impact on multiple sclerosis (MS) and cognitive impairment. The study employed various techniques to assess the gut microbiota composition, inflammation levels, and cognitive functions in experimental autoimmune encephalomyelitis (EAE) mice.
Our findings indicated that treatment with an optimal dose of A. muciniphila notably reduced neuropathology and the severity of symptoms in the EAE model. We observed significant improvements in gut health, including enhanced microbiota diversity and a healthier balance between different bacterial groups. Additionally, A. muciniphila improved the intestinal barrier and decreased harmful immune responses in both the gut and central nervous system.
We also noted that this probiotic could partly mitigate cognitive impairments and reduce neuroinflammation linked to the NLRP3 pathway. This suggests a promising role for A. muciniphila in managing autoimmune disorders and related cognitive issues, such as those experienced in MS. Overall, our research contributes valuable insights into the potential of probiotics as therapeutic agents in these complex health conditions.
Our findings indicated that treatment with an optimal dose of A. muciniphila notably reduced neuropathology and the severity of symptoms in the EAE model. We observed significant improvements in gut health, including enhanced microbiota diversity and a healthier balance between different bacterial groups. Additionally, A. muciniphila improved the intestinal barrier and decreased harmful immune responses in both the gut and central nervous system.
We also noted that this probiotic could partly mitigate cognitive impairments and reduce neuroinflammation linked to the NLRP3 pathway. This suggests a promising role for A. muciniphila in managing autoimmune disorders and related cognitive issues, such as those experienced in MS. Overall, our research contributes valuable insights into the potential of probiotics as therapeutic agents in these complex health conditions.
Read More
Most Useful Reviews
8
Hormone regulation
Very good. I have ordered these pumpkin seeds multiple times due to their excellent quality. They're organic, clean, and packed with protein and iron, which are beneficial for regulating female hormones. The package size is generous at around half a kilo, and the seeds have a delightful taste, being unsalted and unroasted. I will definitely purchase them again.
Read More
8.8
Healthy breakfast
Tasty and high quality. I’ve ordered these pumpkin seeds for myself and my mother before. She enjoys them every morning for breakfast, finding them very healthy. I use them as part of a women's seed cycle, and they taste great as a snack or in bread. They have been beneficial for managing my autoimmune disorder.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
9.5
Impact of protein therapy on SAPHO
SAPHO syndrome with bone destruction in the lumbar vertebral endplates: a case report.
Evaluates protein treatment effectiveness
We explored the case of a young woman suffering from SAPHO syndrome, a rare inflammatory condition linked to autoimmune disorders. She presented with painful symptoms such as low back pain and joint discomfort, along with skin issues like acne. Despite utilizing high doses of non-steroidal anti-inflammatory drugs, her condition showed no improvement.
The patient was then treated with adalimumab, a type of protein therapy, which was administered bi-weekly. We observed remarkable changes; shortly after starting the treatment, both the disease activity and functional assessments improved significantly. This led to a steady reduction in symptoms, and after three years, she enjoyed a complete relief from pain, showing no signs of worsening bone damage.
This case highlights the potential effectiveness of protein treatment for managing autoimmune disorders like SAPHO syndrome. It demonstrates that when other treatments fail, adalimumab may offer hope and significant relief to patients struggling with such complexities.
The patient was then treated with adalimumab, a type of protein therapy, which was administered bi-weekly. We observed remarkable changes; shortly after starting the treatment, both the disease activity and functional assessments improved significantly. This led to a steady reduction in symptoms, and after three years, she enjoyed a complete relief from pain, showing no signs of worsening bone damage.
This case highlights the potential effectiveness of protein treatment for managing autoimmune disorders like SAPHO syndrome. It demonstrates that when other treatments fail, adalimumab may offer hope and significant relief to patients struggling with such complexities.
Read More
9.5
Effective treatment for autoimmune encephalopathy
Acute onset of anti-IgLON5 disease with meningeal enhancement: a case report.
Moderate relevance regarding treatment effectiveness
We explored the intriguing case of a 78-year-old man diagnosed with anti-IgLON5 disease. This autoimmune condition is known for its unique symptoms and often unpredictable behavior. In this instance, the patient experienced sudden onset of encephalopathy, which included fever and altered consciousness—unusual first signs for this condition.
Imaging studies revealed surprising findings, including thickening and enhancement of the dura mater, as well as lesions in various brain regions. With the detection of IgLON5 antibodies in both his serum and cerebrospinal fluid (CSF), we were able to confirm the diagnosis of anti-IgLON5 disease. Treatment with intravenous methylprednisolone and immunoglobulin proved successful; the patient showed remarkable improvement shortly thereafter, with follow-up imaging indicating resolution of the abnormal findings.
While this case underscores the potential effectiveness of certain protein treatments in mitigating symptoms of autoimmune disorders, it also emphasizes the need for comprehensive diagnostics. The swift response to treatment not only alleviated symptoms but also significantly improved the patient's quality of life. Timeliness in diagnosis and the use of immune therapies appear to be key factors in managing such complex diseases.
Imaging studies revealed surprising findings, including thickening and enhancement of the dura mater, as well as lesions in various brain regions. With the detection of IgLON5 antibodies in both his serum and cerebrospinal fluid (CSF), we were able to confirm the diagnosis of anti-IgLON5 disease. Treatment with intravenous methylprednisolone and immunoglobulin proved successful; the patient showed remarkable improvement shortly thereafter, with follow-up imaging indicating resolution of the abnormal findings.
While this case underscores the potential effectiveness of certain protein treatments in mitigating symptoms of autoimmune disorders, it also emphasizes the need for comprehensive diagnostics. The swift response to treatment not only alleviated symptoms but also significantly improved the patient's quality of life. Timeliness in diagnosis and the use of immune therapies appear to be key factors in managing such complex diseases.
Read More
9
Targeted HS delivery alleviates RA
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.
High relevance to RA treatment
We explored a new strategy to treat rheumatoid arthritis (RA) by using nanoparticles to deliver hydrogen sulfide (HS) directly to affected joints. Our research focused on how effectively these nanoparticles, called NaHS@Cy5@MS@SP, could target specific cells involved in inflammation and tissue damage in RA. By slowly releasing HS in the synovium, we aimed to combat the negative effects of inflammation caused by fibroblast-like synoviocytes (FLSs).
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Read More
9
Hydrogel enhances uveitis treatment
Peptide-based hydrogel co-assembled with antibody-drug for enhanced retinal cell uptake and attenuated experimental autoimmune uveitis.
Directly addresses autoimmune treatment
We investigated a new approach to tackle chronic autoimmune eye diseases like uveitis. Our attention focused on a unique drug delivery system that combines a peptide-based hydrogel with secukinumab (SEK), an antibody specifically designed to neutralize IL-17A. This combination targets retinal pigmented epithelium (RPE) cells, helping to enhance the treatment's effectiveness.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Read More
8
Comparative study on RA treatments
Comparative effectiveness of subcutaneous sarilumab 200 mg biweekly, subcutaneous Tocilizumab 162 mg biweekly, and intravenous Tocilizumab 8 mg/kg every 4 weeks in patients with rheumatoid arthritis: a prospective cohort study.
Focus on IL-6R inhibitors
We aimed to compare how effective different medications that target the interleukin-6 receptor (IL-6R) are for treating rheumatoid arthritis (RA). This included subcutaneous sarilumab, subcutaneous tocilizumab, and intravenous tocilizumab. In our study, we involved patients with RA who had never received IL-6R inhibitors before and were starting these treatments.
Our findings showed that those who started with sarilumab saw a significant decrease in disease activity compared to those using subcutaneous tocilizumab. However, there were no substantial differences between the intravenous and subcutaneous forms of tocilizumab. This brings us to an important consideration regarding the cost of treatments, particularly between the subcutaneous options, including biosimilars, and sarilumab.
While it’s promising to see variations in effectiveness among these protein-based treatments, it’s crucial for patients and healthcare providers to weigh the benefits against the costs when making treatment decisions.
Our findings showed that those who started with sarilumab saw a significant decrease in disease activity compared to those using subcutaneous tocilizumab. However, there were no substantial differences between the intravenous and subcutaneous forms of tocilizumab. This brings us to an important consideration regarding the cost of treatments, particularly between the subcutaneous options, including biosimilars, and sarilumab.
While it’s promising to see variations in effectiveness among these protein-based treatments, it’s crucial for patients and healthcare providers to weigh the benefits against the costs when making treatment decisions.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Healthy breakfast
Tasty and high quality. I’ve ordered these pumpkin seeds for myself and my mother before. She enjoys them every morning for breakfast, finding them very healthy. I use them as part of a women's seed cycle, and they taste great as a snack or in bread. They have been beneficial for managing my autoimmune disorder.
Read More
8
Hormone regulation
Very good. I have ordered these pumpkin seeds multiple times due to their excellent quality. They're organic, clean, and packed with protein and iron, which are beneficial for regulating female hormones. The package size is generous at around half a kilo, and the seeds have a delightful taste, being unsalted and unroasted. I will definitely purchase them again.
Read More
